東海大學國際學院--永續學程師資-許員豪 副教授

許員豪 副教授


最高學歷 : 美國加州大學河濱分校 生物化學所博士

辦公室電話: 32230

e-mail : howardhsu@thu.edu.tw

E-mail

howardhsu@thu.edu.tw

分機

辦公室:32230

最高學歷

美國 加州大學河濱分校 生物化學所博士

重要經歷

東海大學化學系副教授 (2015/8  至今)
東海大學化學系助理教授 (2011/8 – 2014/7)

專長

老化疾病
生物化學
生醫質譜學

    普通生物學

    生物化學

    生醫質譜學

期刊論文(2009年以後)

1. Cao J, Hsu YH, Li S, Woods VL Jr and Dennis EA.,2013,Structural Basis of Specific Interactions of Lipoprotein-Associated Phospholipase A2 with HDL Revealed by Hydrogen Deuterium Exchange Mass Spectrometry.,J Lipid Res., (SCI).

2. Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL Jr, McCammon J, Dennis EA. ,2013,Fluoroketone Inhibition of Ca2+-Independent Phospholipase A2 through Binding Pocket Association Defined by Hydrogen/Deuterium Exchange and Molecular Dynamics.,JACS, (SCI)

3. Bucher D, Hsu YH, Mouchlis VD, Dennis EA and McCammon J.,2013,Insertion of the Ca2+-Independent Phospholipase A2 into a Phospholipid Bilayer via Coarse-Grained and Atomistic Molecular Dynamics Simulations.,PLOS Computational Biology, (SCI)

4. Hsu YH, Dumlao DS, Cao J and Dennis EA. ,Assessing Phospholipase A2 Activity toward Cardiolipin by Mass Spectrometry.,PLoS One, (SCI).

5. Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell, Sun W, Wang X, Hsu YH, Hughes G, Su Z, Zhang M, Esteve-Rudd J, Lopes VS, Williams DS, Molday RS, Shaw PX, Dennis EA, and Zhang K,2012,Essential role of elovl4 in very long chain fatty acid synthesis and retinal function.,J Biol Chem,

6. Dennis EA, Cao J, Hsu YH, Magrioti V and Kokotos G.,2011,Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention.,Chemical Reviews, (SCI).

7. Hsu YH, Traugh, JA. ,2011,Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation.,J. Vis. Exp.,

8. Cao J, Hsu YH, Li S, Woods VL Jr and Dennis EA. ,Lipoprotein-Associated Phospholipase A(2) Interacts with Phospholipid Vesicles via a Surface-Disposed Hydrophobic α-Helix.,Biochemistry, (SCI).

9. Kokotos G, Hsu YH, Burke JE and Dennis EA. ,2010,Potent and selective fluoroketone inhibitors of Group VIA calcium-independent phospholipase A2.,J Med Chem., (SCI).

10. Hsu YH and Traugh JA. ,Reciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysis.,PLoS One, (SCI).

11. Hsu YH, Burke JE, Li S, Woods VL Jr and Dennis EA. ,2009,Localizing the membrane binding region of Group VIA Ca2+-independent Phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry., J Biol Chem.,.

12. Barbayianni E, Stephens D, Grkovich A, Magrioti V, Hsu YH, Dolatzas P, Kalogiannidis D, Dennis EA and Kokotos G. ,2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. ,Bioorg Med Chem., (SCI).